Formulation and physical evaluation of Gnetum gnemon L. peel extract tablets using variation concentration of Na-CMC and starch 1500
Keywords:
Gnetum gnemon L., Peel extract tablets, Na-CMC, Starch 1500Abstract
Gnetum gnemon L. peel extract contains flavonoid compounds, which are used to lower cholesterol levels. It needs to be formulated into tablets to maximize the potential of the Gnetum gnemon L. peel extract. This research aims to determine the effect of variations in Na-CMC and starch 1500 concentrations on the physical properties of granules and tablets. The method used was wet granulation, using variations in Na-CMC and starch 1500 concentrations Formula 1 (5%: 6%), Formula 2 (3%: 8%), and Formula 3 (1%: 10%). The evaluation included the physical properties of granules (flow rate, angle of repose, compressibility) and the physical properties of tablets (organoleptic, weight uniformity, hardness, friability, and disintegration time). The data obtained were then analyzed statistically. The results showed that the addition of Na-CMC binder and starch 1500 disintegrant affected the granules and tablets. Formula 1 produces granules and tablets with better physical properties compared to Formula 2 and Formula 3. This research concludes that the concentration of Na-CMC and starch 1500 affects the physical properties and Formula 1 is the best formula with a ratio of Na-CMC (5%) and starch 1500 (6%).
References
[1] Alfitha RN, Dahliah, Wiriansya EP, Rahmawati, Indarwati RP. Pengaruh Terapi Bekam Terhadap Kadar Kolesterol Total Pada Pasien Hiperkolesterolemia di Klinik Hamdalah Makassar. Fakumi Med J J Mhs Kedokt. 2023;3(8):563–72.
[2] Hastuty YD. Perbedaan Kadar Kolesterol Orang Yang Obesitas Dengan Orang Yang Non Obesitas. J Kedokt dan Kesehat Malikussaleh. 2018;1(2):47.
[3] Badan Kebijakan Pembangunan Kesehatan. Survei Kesehatan Indonesia. Kemenkes. 2023.
[4] Handayani M, Simatupang A. The Use of Station in Hypercholesterolemia. Maj Kedokt UKI. 2019;XXXV(3):96–103.
[5] Ramkumar S, Raghunath A, Raghunath S. Statin Therapy: Review of Safety and Potential Side Effects. Acta Cardiol Sin. 2016;32(6):631–9.
[6] Wardani VR, Fatimah S, Nadia, Cahyani IM. Aktivitas Ekstrak Etanol Kulit Melinjo (Gnetum gnemon L.) Sebagai Antihiperkolesterol. Media Farm Indones. 2019;14(1):1466–70.
[7] Husnawati, Hasan AEZ, Puspita CA, Setiyono A. Efektivitas Ekstrak Kulit Melinjo (Gnetum gnemon) sebagai Penurun Kadar Asam Urat pada Tikus Putih (Rattus norvegicus) Hiperurisemia. Curr Biochem. 2020;7(1):21–8.
[8] Arief IM, Novriansyah R, Budianto IT, Harmaji MB. Potensi Bunga Karangmunting (Melastoma malabathricum L.) Terhadap Kadar Kolesterol Total Dan Trigliserida Pada Tikus Jantan Hiperlipidemia yang Diinduksi Propiltiourasil. Prestasi. 2012;1:32.
[9] Pratiwi PD, Citrariana S, Gemantari BM. Bahan Tambahan dalam Sediaan Tablet: Review. Sint J Famasi Klin dan Sains Bahan Alam. 2023;3(2):41–8.
[10] Endriyatno NC, Wikantyasning ER. Optimasi Formula Tablet Ekstrak Daun Sirsak (Annona muricata L.) dengan Bahan Pengikat CMC Na dan Penghancur Explotap Menggunakan Metode Factorial Design. Universitas Muhammadiyah Surakarta; 2018.
[11] Manno MR, Setianto AB. Optimasi Campuran Avicel 101 Dan Laktosa Sebagai Bahan Pengisi Pada Tablet Dispersi Padat Tadalafil Dengan Metode Granulasi Basah. J Ilmu Farm dan Farm Klin. 2022;19(2):95–102.
[12] Puspita P.A.P, Dewantara IGN., Arisanti CI. Formulasi Tablet Parasetamol Kempa Langsung Menggunakan Eksipien Co-Processing dari Amilum Singkong Partially Pregelatinized dan Gom Akasia. J Farm Udayana. 2014;11(2):28–34.
[13] Leon L, Lieberman HA, Kanig JL. The Theory and Practice of Industrial Pharmacy. 4th ed. Khar RK, Vyas S, Ahmad FJ, Jain GK, editors. New Delhi: CBS Publishers & Distributors; 2018.
[14] Depkes RI. Farmakope Indonesia. Edisi 3. Jakarta: Departemen Kesehatan Republik Indonesia; 1979.
[15] Bestari AN, Sulaiman TNS, Rohman A. Formulasi Orally Disintegration Tablet (ODT) Meloksikam dengan Variasi Komposisi Ac-Di-Sol Dan Kollidon Cl® sebagai Bahan Penghancur. Maj Farm. 2016;12(2):453–65.
[16] Sulaiman TNS. Teknologi dan Formulasi Sediaan Tablet. Yogyakarta: PT. Mitra Ummat Communications Indonesia; 2007.
[17] Utami YP, Umar AH, Syahruni R, Kadullah I. Standardisasi Simplisia dan Ekstrak Etanol Daun Leilem (Clerodendrum minahassae Teisjm. & Binn.). J Pharm Med Sci. 2017;2(1):32–9.
[18] Saifudin A, Rahayu V, Teruna HY. Standarisasi Bahan Obat Alam. Yogyakarta: Graha Ilmu; 2011.
[19] Auwal MS, Saka S, Mairiga IA, Sanda KA, Shuaibu A, Ibrahim A. Preliminary Phytochemical and Elemental Analysis of Aqueous and Fractionated Pod Extracts of Acacia nilotica (Thorn mimosa). Vet Res forum an Int Q J. 2014;5(2):95–100.
[20] Fuentes-González KI, Villafuerte-Robles L. Powder Flowability as a Functionality Parameter of The Excipient GalenIQ 720. Int J Pharm Pharm Sci. 2014;6(9):66–74.
[21] Aulton ME, Taylor KMG. The Design and Manufacture of Medicines. 4th ed. Churchill Livingstone; 2001.
[22] Shah DS, Moravkar KK, Jha DK, Lonkar V, Amin PD, Chalikwar SS. A Concise Summary of Powder Processing Methodologies for Flow Enhancement. Heliyon. 2023;9(6):1–17.
[23] Wardhana AE, Rani KC, Pradana AT, Jayani NIE. Formulasi Granul Minuman Fungsional Kombinasi Ekstrak Etanol Daun Jambu Biji (Psidium guajava) dan Ekstrak Etanol Biji Klabet (Trigonella foenum-graecum). Media Pharm Indones. 2021;3(4):235–44.
[24] Elisabeth V, Yamlean PVY, Supriati HS. Formulasi Sediaan Granul Dengan Bahan Pengikat Pati Kulit Pisang Goroho (Musa acuminafe L.) dan Pengaruhnya Pada Sifar Fisik Granul. PHARMACON J Ilm Farm. 2018;7(4):1–11.
[25] Syukri Y. Teknologi sediaan obat dalam solida. Vol. 13, Angewandte Chemie International Edition, 6(11), 951–952. 2018. 10–27 p.
[26] Syukuri Y. Teknologi Sediaan Obat Dalam Bentuk Solid. 1st ed. Yogyakarta: Universitas Islam Indonesia; 2018.
[27] Irawan ED, Sari LORK, Cahyaningrum N. Optimasi Sodium Croscarmellose dan Pati Jagung Pregelatinasi dalam Orally Disintegrating Tablet Setirizin Dihidroklorida. J Farm Indones. 2022;14(2):136–46.
[28] Rahmawati TE, Lewi I. Effect of Disintegrating Agents on Red Ginger (Zingiber officinale Roxb) Dry Extract Fast Disintegrating Tablets Using Direct Compression Method. Media Farm Indones. 2024;19(2).
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